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1. Artificial moon is being developed by which country

A. USA B. Japan C. China D. KSA

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2. The reduced dose requirement of isoniazid is observed in patients who are

A. Fast acetylator B. Slow acetylator C. G6PD deficient D. CYP450 induced

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3. 3,5-dinitrobenzoic acid will give how many peaks in HNMR

A. 4 B. 3 C. 2 D. 1

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4. Which of the following drugs works as a proteosome inhibitor

A. Nilotinib B. Infliximab C. Bortezomib D. Filgrastim

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5. All of the following are typical cholinergic effects EXCEPT

A. a decrease in heart rate and contraction of bronchial muscle B. a decrease in conduction velocity through the AV node C. an increase in sweat secretion D. an increase in pupillary diameter

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6. Agarose is a polysaccharide, composed of

A. D-galactose and agarobiose B. D-glucuronic acid and sulfated D-glucuronic acid C. D-glucuronic acid and glucosamine D. D-galactose and 3,6-anhydro-L-galactopyranose

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7. Which of the following forces is dictated by entropic effects

A. atom-atom repulsion based on the Pauli Exclusion principle B. electrostatic interactions C. hydrophobic interactions D. charge-transfer interactions

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8. Which of the following functional groups is a classical isostere for -CH=

A. -CH3 B. -NH- C. -N= D. COOH

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9. As much as 70 per cent of all the APIs needed by India to manufacture drugs come from

A. China B. India C. Taiwan D. Belgium

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10. Alogliptin, saxagliptin, vildagliptin have a structural feature common that is responsible for reaction with DPP-4. What is that

A. Nitrilo group B. β-aminoacid group C. Adamantane ring D. Pyrollidine

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11. The approximate δ value of methyl proton in 1H-NMR is

A. 1.3 B. 1.5 C. 0.9 D. 2.5

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12. 100 proof ethanol means it is

A. 100% B. 75% C. 60% D. 50%

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13. Select the drug indicated for extended drug resistance tuberculosis (XDR TB)

A. Linezolid B. Moxifloxacin C. Tyrocidin D. Azithromycin

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14. Which of the following quantities is not changed at different magnetic field strength

A. Chemical shift (in Hz) B. Nuclear spin population in an energy state C. J-coupling constant D. Energy difference between two energy states of nuclei with nonzero spin quantum number

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15. Choose the WRONG statement about mass spectrometry with ESI

A. It is very unlikely for adducts to occur during ESI. B. ESI can be used for thermally labile analytes. C. Adjusting the pH might enhance the generation of ions. D. It has easy compatibility with LC

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16. Which are the host cell membrane receptors that the outer coat protein gp-120 of HIV binds to are

A. CD4 and CCR5 B. pepsin and adenylyl cyclase C. IP3 and cytochrome-c D. bicoid and nanos

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17. In LC-MS instrument, interface is applied between

A. LC column and mass separator B. Injection and ion source C. LC column and ion source D. LC column and detector

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18. Microwave spectroscopy is generally used to detect

A. Functional groups B. Double bonds C. Isotopes D. Unpaired electrons

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19. Which of the following is not true

A. Magnets (200 MHz-900 MHz) are made of superconducting wires B. Room temperature shims are in a liquid nitrogen vessel C. Liquid helium and liquid nitrogen are needed to maintain the magnetic field D. The magnet solenoid is in a liquid helium vessel

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20. The purpose of shimming is to

A. Stabilize the static magnetic field B. Obtain homogeneity of the static magnetic field C. Find the lock frequency D. Obtain homogeneity of the B1 field