---

1. Volhard's method of chloride ion determination

A. is back titration with ammonium thioscyanat B. is direct titration ammonium thioscyanate C. uses dichlorofluorescein as indicator D. uses potassium chromate

---

2. Which of the following is an ergot derivative

A. Bergapten B. Bretylium C. Bupropion D. Bromocriptine

---

3. Pramipexole is

A. Antipsychotic B. Antidepressant C. Anthelmentic D. Antiparkinsonial

---

4. Single letter symbol for arginine is

A. K B. D C. R D. G

---

5. Penicillin degradation is prevented at pH

A. 4 B. 5 C. 6 D. 8

---

6. Which of the following titration method should be protected from light

A. Volhard B. Adsorption C. Mohr D. Gay Lussac

---

7. If the rate constant for a first order reaction is k, the time(t) required for the completion of 99% of the reaction is given by

A. t = 4.606/k B. t = 2.303/k C. t = 0.693/k D. t = 6.909/k

---

8. Assessment, control, communication and review of risks to the quality of the drug product across the product life cycle is

A. QbD B. QRM C. PAT D. QTPP

---

9. Which one of the following is a Histamine H1-receptor antagonist

A. 4-(5H-dibenzola,d] cyclohepten-5-ylidene)-1-methyl pyridine hydrochloride B. 4-(5H-dibenzola,d] cyclohepten-5-ylidene)-1-methyl pyrimidine hydrochloride C. 4-(5H-dibenzo[a,d] cyclohepten-5-ylidene)-1-methyl piperidine hydrochloride D. 4-(5H-dibenzoja,d] cycloheptane-5-ylidene)-1-methyl piperidine hydrochloride

---

10. QbD is described in ICH guidelines

A. Q8 Part I B. Q8 Part II C. Q9 D. Q10

---

11. Which is the correct long term stability condition for zone IVb

A. 40 °C ± 2 °C/75% ± 5% B. 30 °C ± 2 °C/65% ± 5% C. 30 °C ± 2 °C/75% ± 5% D. None

---

12. Which medicine works by binding to the glycoprotein llb/llla receptor, reversibly inhibiting platelet aggregation

A. Clopidogrel B. Warfarin C. Ticlopidine D. Eptifibatide

---

13. Which is the most stable structure of 1-isopropyl-4-methylcyclohexane

A. Both groups axial B. Both groups equitorial C. Bigger group axial smaller equitorial D. Bigger group equitorial smaller group axial

---

14. Nuclei having either the number of protons or neutrons as odd have spin

A. Integral spin B. Half integral spin C. Zero spin D. Positive spin

---

15. Only percent of the effluent of the liquid chromatography must be introduced in the mass spectrometer

A. 1-20% B. 1-15% C. 1-5% D. Below 1%

---

16. In AAS, ionization of analyte atoms in flame/plasma can be suppressed by

A. EDTA or other complexing agents B. Addition of KCl to the matrix C. Addition of oxyanions such as sulfate or phosphate D. Internal standards methods

---

17. Furan is aromatic. What is the value of Hukel's n in it

A. 1 B. 2 C. 4 D. 6

---

18. Which feature in the 1H NMR spectrum provides information about the electronic environment of the protons in a compound

A. splitting B. chemical shift C. integral D. number of signals

---

19. What is the relationship between the following two structures

A. tautomers B. stereoisomers C. resonance structures D. constitutional isomers, but not tautomers

---

20. Systemic clearance (CLs) is related with

A. Only the concentration of substances in plasma B. Only the elimination rate constant C. Volume of distribution, half life and elimination rate constant D. Bioavailability and half life