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1. Which of the following is a cytokine inhibitor used as anti-inflammatory?

A. Nimesulide B. Abatacept C. Diclofenac D. Nabumetone

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2. Remdesivir interferes with the action of which viral enzyme?

A. RNA-dependent RNA polymerase B. Exoribonuclease C. DNA-dependent RNA polymerase D. DNA gyrase

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3. Captisol is an excipient based on:

A. PLA polymer B. PLGA polymer C. Cyclodextrin D. PEG

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4. 6-Fluoro-3-oxo-3,4-dihydro-2-pyrazine carboxamide is the IUPAC name of which drug?

A. Ritonavir B. Favipiravir C. Remdesivir D. Pyrazinamide

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5. This reaction mechanism is favored by 3° substrates, low temperatures, polar solvents, and low concentrations of very weak bases.

A. E1 B. E2 C. SN1 D. SN2

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6. Who is the recipient of 'World Entrepreneur of The Year award' for 2020?

A. Vivekchand Sehgal B. Siddarth Lal C. Kiran Mazumdar-Shaw D. Rahul Bajaj

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7. In one of the following sulfonamides, pyrimidine ring is absent. Which is it?

A. sulfosimidine B. sulfadimidine C. sulfadoxine D. sulfisoxazole

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8. Histamine structure is represented by:

A. 3,4-Dihydroxyphenethylamine B. 2-(1-H-Imidazol-5-yl)ethanamine C. 2-(1-H-Imidazol-4-yl)ethanamine D. 2-Amino-3-(1H-imidazol-4-yl) propanoic acid

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9. P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) that:

A. Mediates platelet aggregation B. Mediates WBC stimulation C. Binds to clopidogrel reversibly D. Mediates fibrinolysis

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10. Neopentane and 2-methyl butane are which type of isomers?

A. Positional isomers B. Chain isomers C. Isomers D. Diastereoisomers

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11. Which activity (the signal transduction pathway) of metformin is responsible for the inhibitory effect on glucose production by liver cells?

A. Activation of AMPK B. Inhibition of hormone-sensitive lipase C. Inhibition of mammalian target of rapamycin (mTOR) D. Allosteric regulation by binding to a crucial section of the DNA that makes proteins needed for glucose uptake

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12. Single letter code for pyrrolysine is:

A. P B. J C. O D. Y

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13. Which bacterial enzyme helps the survival of Helicobacter pylori in the stomach?

A. carbonic anhydrase B. urease C. β-lactamase D. transpeptidase

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14. Which of the following amino acids cannot provide a substrate for gluconeogenesis?

A. Leucine B. Tryptophan C. Histidine D. Isoleucine

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15. 1H NMR spectra recorded in CDCI3 solution typically show a resonance at 7.24 ppm. What is this resonance due to?

A. water B. trace HC C. Chloroform D. exchangeable protons

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16. Favipiravir tested as a COVID-19 treatment is a product of which company?

A. Fujifilms B. AstraZeneca C. Safoni team D. Takeda

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17. The drug of choice for Torsades de pointes treatment is:

A. Sotalol B. Ibutilide C. disopyramide D. Magnesiums

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18. 13C chemical shift has a much wider range (<300 ppm) than 'H(<10 ppm) because:

A. The contribution of the diamagnetic shielding of 13C is much larger than 1H due to the small 13C energy B. The contribution of the paramagnetic shielding of 13C is much larger than 1H due to the small 13C energy C. The electron density of 1H is usually spherically symmetrical D. The reason is unknown

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19. Which of the following drugs reduces LDL cholesterol by inhibiting an intestinal transport protein?

A. atorvastatin B. cholestyramine C. ezetimibe D. gemfibrozil

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20. The least abundant amino acid in human proteins is:

A. Leucine B. Lysine C. Cysteine D. Tyrosine