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1. Which enzyme is responsible for carboxylation reaction (transfer of CO₂)

A. Biotin B. Folic acid C. Riboflavin D. Ascorbic acid

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2. The co-receptor responsible for the entry of HIV into the host cell is

A. CCR1 B. CCR5 C. CXCR3 D. CXCR7

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3. Cope rearrangement involves

A. [1,5]-sigmatropic rearrangement B. [4+2]-cycloaddition reaction C. [3,3]-sigmatropic rearrangement D. 6π-electrocyclisation reaction

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4. Which is the only genetically modified crop/food plant approved in India

A. Golden rice B. Bt brinjal C. Bt cotton D. Bt tomato

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5. Azulene is an isomer of

A. Naphthalene B. Quinoline C. Anthracene D. Acridine

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6. Identify a neuraminidase inhibitor

A. Abacavir B. Oseltamivir C. Tenofovir D. Stavudune

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7. The reaction in which phenolic esters can be rearranged by heating with aluminium chloride or boron trifluoride to o-and p-acylphenols is known as

A. Friedel Craft's rearrangement B. Favorski rearrangement C. Gabriel rearrangement D. Fries rearrangement

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8. A compound that shows positive iodoform test is

A. 1-pentanal B. 2-Pentanone C. 3-Pentanone D. 3-Pentanol

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9. An aromatic molecule satisfies Huckel's rule 4n + 2 where n is

A. number of double bonds B. number of π electrons C. an integer D. number of conjugated double bonds

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10. What will be the operating frequency for 13C NMR if 1HNMR operating frequency is 300 MHz for 7 Tesla instrument

A. 50 MHz B. 70 MHz C. 100 MHz D. 300 MHz

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11. Alkenes can be obtained from aldehydes or ketones by

A. Wittig reaction B. Clemensons reduction C. Wittig rearrangement D. Claisen rearrangement

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12. Elvitegravir, an antiretroviral drug, is

A. histonedeacetylase inhibitor B. integrase inhibitor C. protease inhibitor D. reverse transcriptase inhibitor

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13. Doebner-Miller reaction is the organic reaction of –––––– to form quinoline

A. aniline with α-β-unsaturated carbonyl compound B. aniline with alkoxymethylenemalonic ester or acyl malonic ester C. 2-aminobenzaldehydes with ketone D. aniline with glycerol in H₂SO₄ + nitrobenzene

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14. Which one is the first drug developed with application of structure-based drug design

A. Dorzolamide B. Vigabatrin C. Saralasin D. Sibutramine

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15. Sequesterpeniod ring is present in

A. Taxol B. Artemesinin C. Esorelin D. Saxitoxin

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16. Which of the following properties is NOT a characteristic of microemulsions

A. high surfactant content B. droplet size greater than 1 μm C. transparent systems D. thermodynamically stable

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17. What would be the drug plasma concentration immediately after an intravenous dose of 2 m with volume of distribution (V_D) of 20L is given to a 65-kg male patient? (V_D = dose/C_P0)

A. 0.1 μg/dL B. 1 μg/dL C. 10 μg/dL D. 100 μg/dL

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18. Reasons for capping in tablet formulations are all EXCEPT

A. excessive force of compression B. insufficient binder C. entrapment of air during processing D. excessive lubricant

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19. Which of the following agents would produce a long-term inhibition of reduced gastric acid secretion through an irreversible mechanism

A. Pantoprazole B. Cimetidine C. Fexofenadine D. Loratidine

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20. Fomivirsen is an example of which of the following biological products

A. A liposomal formulation B. An antisense oligonucleotide C. An siRNA molecule D. A monoclonal antibody