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1. Which of the following is not a true statement?

A. Dioxanes are 6-membered ring ethers B. Furans are 5-membered ring ethers C. Oxiranes are 3-membered ring ethers D. Oxetanes are 5-membered ring ethers

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2. Esters and amides are most easily made by nucleophilic acyl substitution reactions on:

A. Alcohols B. Acid chlorides C. Carboxylates D. Carboxylic acid

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3. Nifedipine belongs to which chemical class?

A. 1,2-Dihydropyridine B. 1,4-Dihydropyrimidine C. 1,4-Dihydropyridine D. 1,4-Dihydropyridine-4-one

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4. The acronym CDSCO stands for:

A. Control Drugs’ Society Central Office B. Central Drugs Standard Control Organization C. Community Disease Spread Control Organization D. None of the above

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5. Urea cycle occurs in:

A. Mitochondria B. Cytoplasm C. Mitochondria and cytosol D. Kidney cells

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6. The statin drugs are given at night:

A. To decrease stomach upset B. Because cholesterol synthesis increases at night C. To increase absorption D. Because food intake decreases absorption

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7. The mode of action of ethylene oxide as a sterilization agent is by:

A. Oxidation B. Reduction C. Alkylation D. Protein precipitation

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8. Blood and blood products are governed by which Schedule of the Drugs & Cosmetics Act 1940?

A. Schedule B B. Schedule C and C1 C. Schedule G D. Schedule W

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9. Indian Patent Controller General gave a compulsory license to NATCO to manufacture Bayer Pharma’s anti-cancer drug ‘Nexavar’ because Bayer Pharma ______.

A. Was ‘evergreening’ the patent of the drug molecule B. Had forged clinical trial records to obtain the patent C. Had obtained the patent only for Germany and not for India D. Was selling the patented drug at an unaffordable price to Indian patients

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10. MRT is defined as the ratio of:

A. AUC to AUMC B. AUMC to AUC C. AUC to Vd D. AUMC to Vd

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11. Which of the following techniques would be most useful to identify and quantify the presence of a known impurity in a drug substance?

A. NMR B. MS C. IR D. HPLC

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12. The ring system in lidocaine is:

A. Xylenol B. Cresol C. Xylidine D. Xylene

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13. APS (Ammonium persulphate) is used in SDS-PAGE for:

A. Preventing oxidation B. Cross-linking C. Its role as a catalyst D. Free radical formation

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14. In drug development, racemic switch is introduced for the synthesis of:

A. Meso compounds B. Racemic mixture C. Eutomer D. Distomer

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15. Which of the following organisms is widely used as a biocontrol in organic farming?

A. Rhizobium tropicii B. Trichoderma viridis C. Fusarium oxysporum D. Nostoc muscorum

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16. Instantaneous distribution to most body tissues and fluids is assumed in which of the following models?

A. One-compartment model B. Two-compartment model C. Multi-compartment model D. None of the above

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17. Aspirin is not used in:

A. Inflammation B. Pain C. Heart stroke D. Peptic ulcer

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18. Atropine, found in Atropa belladonna, is sometimes used in dilating pupils during an eye exam. Which of the following functional groups is NOT in atropine?

A. Ketone B. Ester C. Alcohol D. Benzene Ring

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19. Which of the following effects would a kappa-selective agonist cause?

A. Pinpoint pupils B. Respiratory depression C. Constipation D. Urinary retention

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20. Inhibition of arabinosyltransferase activity results from the administration of:

A. Terbinafine B. Pyrazinamide C. Isoniazid D. Ethambutol