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1. Which of the following is an immunosuppressant?

A. Cyclophosphamide B. Cyclosporine C. Cyclobenzaprine D. Tranexamic acid

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2. @@What are the absolute configurations of the chiral carbons in the given compound?

A. R, R B. S, S C. R, S D. S, R

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3. Friedrich type I hyperlipidemia is due to excess of:

A. HDL B. LDL C. IDL D. Chylomicrons

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4. FMC Corporation has developed patented aqueous enteric coating called as:

A. Aquateric B. Aquateric and Eudgrit C. HPMC 50 D. Aquateric, Eudgrit and HP55

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5. Antiemetic drugs used to treat vomiting due to cytotoxic drug treatment act at all the receptors EXCEPT:

A. 5HT1, D1 antagonist B. 5HT2, D2 antagonist C. 5HT3, D2, NK1 antagonist D. H1 antagonist

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6. When logP value of a drug is -1, what will be the conclusion about its solubility?

A. Solubility of drug is 2 times in water than octanol B. Solubility of drug is 2 times in octanol than water C. Solubility of drug is 10 times in octanol than water D. Solubility of drug is 10 times in water than octanol

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7. @@Arrange the compounds in order of increasing reactivity toward electrophilic aromatic substitution (lowest first).

A. III, II, I, IV B. IV, II, I, III C. III, I, II, IV D. I, II, III, IV

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8. The function of ubiquitin is:

A. To assist attachment of RNA polymerase to the promoter B. To aid in the removal of introns from mRNA C. To attach to proteins to signal they are to be disassembled by a proteosome D. To prevent attachment of mRNA to the ribosome

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9. _______ & _______ are closely interrelated functions.

A. Planning & Controlling B. Planning & Organizing C. Organizing & Controlling D. Staffing & Controlling

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10. Prolonged use of steroids may cause antihistamine?

A. Hypoglycemia B. Hypotension C. Decrease in bone matrix protein D. Early healing of wound

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11. The pharmacokinetic 'half-life' of which one of the following resembles to its pharmacodynamic 'half-life'?

A. Morphine B. Terfenadine C. Isoprenaline D. Suxamethonium

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12. The renal clearance of inulin is used as a measurement of:

A. Effective renal blood flow B. Active renal secretion C. Glomerular filtration rate D. Intrinsic enzyme activity

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13. Euphoria is associated with ______ receptors, while dysphoria is associated with ______ receptors.

A. mu, kappa B. kappa, mu C. mu, delta D. kappa, delta

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14. Enzyme action can be influenced by the presence of inhibitors. Which of the following statements correctly matches the type of inhibitor with its effect on an enzyme?

A. Irreversible: renders the enzyme permanently inactive B. Competitive: inhibitor binds only to ES complex, only important when [S] high, Vmax lower, Km lower C. Noncompetitive: can be overcome with high [S], Vmax unchanged, Km higher D. Uncompetitive: cannot be overcome with high [S], Vmax lower, but Km unchanged

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15. @@@The major product formed in the reaction of quinoline with potassium amide (KNH2) in liquid ammonia is:

A. (structure missing) B. (structure missing) C. (structure missing) D. (structure missing)

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16. Neoprene is:

A. Polyurethane B. Polychloroprene C. Acrylonitrile-butadiene-styrene D. Polyisoprene

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17. Rochelle salt is:

A. Potassium sodium tartrate B. Ferrous ammonium sulfate C. Aluminium potassium sulfate D. Copper sulfate

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18. Which of the given conclusions is logically valid and is inferred from the above arguments:
All professors are researchers
Some scientists are professors

A. All scientists are researchers B. All professors are scientists C. Some researchers are scientists D. No conclusion follows

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19. K-band is the absorption band arising from π → π* transitions of:

A. Conjugated polyenes B. Alkenes, alkynes, nonconjugated polyenes and polyynes C. Benzene at 184 nm, 204 nm D. Benzene at 256 nm

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20. Lidocaine is given either intravenously or intramuscularly because:

A. The drug undergoes 90% first-pass hepatic metabolism B. The drug causes severe gastric irritation C. The drug is inactivated by gastric acid D. The drug causes severe nausea and vomiting