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1. The double bond in cholesterol is located in ring:

A. A B. B C. C D. D

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2. Which eicosanoid causes activation of platelets?

A. Prostaglandin G B. Thromboxane A C. Thromboxane B D. Prostacyclin

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3. Which of the following is a zymogen?

A. Trypsin B. Plasmin C. Thrombin D. Factor X

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4. Camptothecin is a therapeutic drug that directly inhibits:

A. Telomerase B. DNA polymerase C. Type I topoisomerases D. Type II topoisomerases

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5. 10-11 epoxide is a metabolic product of:

A. Phenytoin B. Carbamazepine C. Valproic acid D. Ethusuximide

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6. The cobalamin (vitamin B12) and one-carbon metabolism are interrelated because cobalamin is required for:

A. regenerating methionine from homocysteine using methyl-THF B. oxidation of odd-numbered chain-length fatty acids C. reduction of lipid peroxides that cause hemolysis D. reduction of dihydrofolate to tetrahydrofolate

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7. Which of the following second messengers functions at the membrane without diffusing into the cytosol?

A. Ca2+ B. cyclic AMP/GMP C. IP3 D. diacylglycerol

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8. Apoptosis is triggered by:

A. Nitric oxide B. Superoxide dismutase C. BCL2 D. p53

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9. Which of the following does not inhibit 50S ribosome?

A. Chloramphenicol B. Tetracycline C. Oxazolidinones D. Clindamycin

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10. The conversion of acetophenone to acetanilide is best accomplished by using:

A. Beckmann rearrangement B. Curtius rearrangement C. Lossen rearrangement D. Hofmann rearrangement

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11. Crystalline anionic microporous aluminosilicates are:

A. Calixarenes B. Zeolites C. Amberlites D. Bauxite

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12. C4 plants are more productive than C3 plants because they:

A. are efficient in photosynthesis B. have less photorespiration C. can utilize more nutrients from soil D. have fewer stomata

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13. Which of the following reaction does not produce pyrrole?

A. Pall Knorr synthesis B. Hantzsch synthesis C. Knorr synthesis D. Skraup synthesis

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14. To identify API or pharmaceutical substance, a globally recognized system is:

A. USAN B. INN C. WHO D. BAN

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15. @@Match the following:

A. 1-S, 2-R, 3-Q, 4-P B. 1-R, 2-S, 3-P, 4-Q C. 1-S, 2-P, 3-Q, 4-R D. 1-Q, 2-P, 3-S, 4-R

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16. Rifaximin is approved as orphan drug for the treatment of:

A. Traveller's diarrhea B. Hepatic encephalopathy C. Irritable bowel syndrome D. None of the above

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17. The wound exhibited signs of copious drainage requiring medical intervention. Copious means:

A. Minimal B. Clear C. Maximal D. Foul

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18. Electron-withdrawing but ortho, para directing group is:

A. -NO2 B. -COR C. -CN D. Halide

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19. Spanish foxglove is:

A. Digitalis purpurea B. Digitalis lanata C. Digitalis lutea D. Digitalis thapsi

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20. As per DPCO 2013, new drug/formulation/processes developed by domestic research and development and patented is exempted from price control for a period of:

A. 2 years B. 5 years C. 10 years D. 15 years