NIPER-JEE-QUESTION-PAPER-2014
QUIZ NO 1
TOTAL QUESTIONS = 20
1. Vaccine is not available for which of the hepatitis viral infection?
A. Hepatitis A
B. Hepatitis B
C. Hepatitis C
D. Hepatitis D
2. Which of the following indicators would be most suitable for titration of lactic acid with a strong base? (Lactic acid pKa=3.08)
A. alizarin yellow (pKin = 11.2)
B. methyl orange (pKin = 3.4)
C. phenol red (pKin = 7.9)
D. bromophenol blue (pKin = 3.9)
3. Tranexamic acid antagonizes the action of:
A. alteplase
B. warfarin
C. heparin
D. aspirin
4. The rate limiting step in cholesterol biosynthesis is:
A. Squalene synthase
B. Mevalonate kinase
C. HMG-CoA synthase
D. HMG-CoA reductase
5. The headquarters of Sun Pharma is located at:
A. Mumbai
B. Ahmedabad
C. Baroda
D. New Delhi
6. Gynecomastia is:
A. enlargement of mammary glands in females
B. presence of female type mammary glands in males
C. lactating mammary glands
D. drug induced breast enlargement
7. Identify the detoxifying agent used for antineoplastic therapy with alkylating agent:
A. Amifostine
B. Mesna
C. Leucovorin
D. Dexrazoxane
8. Reaction of alcoholic solution of curcumin with acetic acid and hydrazine hydrate under 60°C for 24 h gives:
A. Diazocurcumin
B. Hydrazinocurcumin
C. Curcuminoxime
D. Curcuminamine
9. Which of the following drugs may cause reversible gynecomastia?
A. Omeprazole
B. Pirenzepine
C. Cimetidine
D. Sucralfate
10. Greater than 90% of serotonin is located here:
A. cerebral cortex
B. raphe nucleus (brain stem)
C. enterochromaffin cells of the GI tract
D. lungs
11. Ondansetron, granisetron, tropisetron interact with its serotonin receptor subtype located in the area postrema, sensory, and enteric nerves:
A. 5HT3
B. 5HT4
C. 5HT1a
D. 5HT1d
12. Antimigrane specificity of ergot alkaloid is mediated by these receptors:
A. adrenergic
B. serotonergic
C. cholinergic
D. dopaminergic
13. Which drug is NOT metabolized by acetylation?
A. Isoniazid
B. Dapsone
C. Hydralazine
D. Metoclopropamide
14. Enzyme catalyzing conversion of angiotensinogen to angiotensin is:
A. serum cholinesterase
B. aspartyl protease
C. dopamine b-hydroxylase
D. phenylethanolamine N-methyltransferase
15. Synthesis site of most circulatory renin is:
A. pulmonary
B. liver
C. kidney
D. brain
16. Receptor type mediating urinary retention associated with 1st-generation H1 antagonists is:
A. adrenergic
B. cholinergic
C. serotonergic
D. GABA-ergic
17. Loading dose of a drug primarily depends on:
A. Volume of distribution
B. Clearance
C. Rate of administration
D. Half-life
18. Therapeutic index is a measure of:
A. Safety
B. Potency
C. Efficacy
D. Selectivity
19. Elimination after 4 half-lives in first-order kinetics is:
A. 84%
B. 93%
C. 80.5%
D. 75%
20. All amino acids except one participate in phase 2 reactions of detoxification:
A. Serine
B. Glycine
C. Glutamine
D. Cysteine
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