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1. Which of the following does not aIr in the official definition of drugs in India?

A. Prevention B. Mitigation C. Diagnosis D. Cure

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2. The enzyme 1.1.1.1 refers to which of the following enzymes?

A. Glutamic dehydrogenase B. Catalase C. Alcohol dehydrogenase D. Phosphorylase

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3. Which of the following correctly lists the compounds in order of decreasing acidity?

A. H₂O > HC≡CH > NH₃ > CH₃CH₃ B. HC≡CH > H₂O > NH₃ > CH₃CH₃ C. CH₃CH₃ > HC≡CH > NH₃ > H₂O D. CH₃CH₃ > HC≡CH > H₂O > NH₃

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4. The hydroboration-oxidation reaction can be characterized as the ______ addition of water to an alkene:

A. Anti-Markovnikov, syn B. Anti-Markovnikov, anti C. Markovnikov, syn D. Markovnikov, anti

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5. Which of the following is a better nucleophile?

A. Strong base B. Strong acid C. Weak base D. Weak acid

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6. The above reaction is known as:

A. Curtius reaction B. Schmidt reaction C. Hofmann rearrangement D. Lossen rearrangement

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7. Which of the following reactions of alkenes is not stereospecific?

A. Bromination (treatment with Br₂ in CHCl₃) B. Hydrogenation (treatment with H₂/Pt) C. Acid-catalyzed hydration (treatment with aqueous H₂SO₄) D. Bromohydrin formation (treatment with Br₂ / H₂O)

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8. How many signals appear in the proton-decoupled ¹³C NMR spectrum of 1,4-dibromo benzene?

A. 1 B. 2 C. 3 D. 4

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9. Which of the following functional groups is likely to be present in a molecule that has peaks in the IR spectrum at 1630-1820 cm⁻¹ (strong, broad), but does not have peaks at 3200-3650 or 1000-1250 cm⁻¹?

A. Alcohol B. Aldehyde or ketone C. Ether D. Ester

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10. Carbamazepine is a lipid-soluble anti-epileptic drug that has a large volume of distribution in obese patients. Which of the following statements is true of the expected carbamazepine disposition in obese patients?

A. The elimination half-life in obese patients is expected to be decreased. B. The elimination half-life in obese patients is expected to be increased. C. As a result, the elimination half-life in obese patients is expected to remain the same. D. Its volume of distribution is expected to decrease.

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11. The plasma drug concentration versus time curve for a two-compartment model is:

A. Q and S B. Q and R C. P and S D. P and R

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12. Which pigment is water-soluble?

A. Chlorophyll B. Carotene C. Anthocyanin D. Xanthophyll

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13. Choose the selective α-1 antagonist.

A. Phentolamine B. Metaraminol C. Phenazocine D. Doxazosin

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14. The population of a new city is 5 million and is growing at 20% annually. How many years would it take to double at this growth rate?

A. 3-4 years B. 4-5 years C. 5-6 years D. 6-7 years

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15. Herceptin is a brand name of:

A. Hyperecin B. Heparin C. Trastuzumab D. Tamoxifen

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16. What drugs do not affect warfarin metabolism?

A. Phenobarbitone B. Benzodiazepines C. Cimetidine D. Rifampicin

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17. At:

A. 4% B. 8% C. 12% D. 16%

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18. Central Pharma Public Sector Undertakings are:
P) Indian Drugs & Pharmaceuticals Limited, Gurgaon
Q) Hindustan Antibiotics Limited, Pimpri, Pune
R) Bengal Chemicals & Pharmaceuticals Limited, Kolkata
S) Karnataka Antibiotics & Pharmaceuticals Limited, Bangalore & Rajasthan Drugs & Pharmaceuticals Limited, Jaipur.

A. P and Q B. P, Q, and S C. Q, R, and S D. P, Q, R, and S