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1. Using the FDA bioequivalence rule, how much variation could a generic drug potentially have from an innovator and still be considered equivalent?

A. 10% B. 20% C. 30% D. 40%

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2. Which of the following descriptions is CORRECT about gyrase?

A. Gyrase is a type I topoisomerase. B. Gyrase requires ATP for its catalysis. C. Gyrase only relaxes supercoiled DNA. D. Gyrase is well conserved from bacteria to human.

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3. In March 2012, India granted its first compulsory license for anti-cancer drug by Indian Patent office to:

A. Khandelwal Lab B. Natco Vs Bayer C. Panacea Biotech D. Sandoz Vs GSK

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4. Why is penicillin G sensitive to acid and enzyme-catalyzed hydrolysis?

A. Ring strain B. A reactive β-lactam carbonyl group C. Nucleophilic influence of the acyl side chain D. All of the answers are correct

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5. Which of the following drugs interacts selectively with a specific subtype of the benzodiazepine receptor and is used to treat insomnia?

A. Alprazolam B. Flumazenil C. Zolpidem D. Chlordiazepoxide

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6. Tropane system is fusion of:

A. Pyrrolidine and piperidine B. Pyrrolidine and pyrimidine C. Pyrrole and pyrazine D. Thiophene and piperidine

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7. DNA in mammal cells is also present in:

A. Mitochondria B. Vesicles C. Endoplasmic reticulum D. Golgi complex

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8. The composition of Silica gel G is:

A. Silica gel without binder B. Silica gel + CaSO4 C. Silica gel + alumina D. Silica gel + MaSO4

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9. Twenty different amino acids found in proteins are normally coded by:

A. 59 codons B. 60 codons C. 61 codons D. 63 codons

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10. DPCO is issued under which act?

A. Drugs and Cosmetics Act B. Essential Commodities Act C. Patent Act D. RTI Act

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11. Which one of the following is second generation H1-antihistamine?

A. Cetirizine B. Cinnarizine C. Pheneramine D. Promethazine

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12. The Chairman of the Investigational New Drug (IND) Committee in India is:

A. Drugs Controller General of India, Government of India B. Secretary, Department of Health Research, Government of India C. Directorate General of Health Sciences, Government of India D. Secretary, Department of Biotechnology, Government of India

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13. Which of the following is not used as enteric coating material?

A. Cellulose acetate phthalate B. Acrylate polymers C. Pectin D. Polyvinyl acetate phthalate

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14. Which of the speculators expects the price of securities to rise in the near future?

A. Bear B. Bull C. Stag D. Lame duck

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15. An information gathering and managing tool that can be used to help identify potential causes of a certain problem or event is/are:

A. Ishikawa diagram B. Fish bone diagram C. PERT-CPM D. A and B

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16. The IPR in India is implemented with:

A. The patent act B. The copyright and trademarks act C. The biological diversity act D. All of the above

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17. The Freundlich adsorption isotherm can be used to model:

A. Multilayer adsorption B. Monolayer adsorption C. Both D. None of the above

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18. For dissolution testing of implants, which apparatus is used?

A. Type 2 B. Type 4 C. Type 7 D. Type 8

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19. Which one is most acidic?

A. Benzoic acid B. p-methoxy benzoic acid C. p-methyl benzoic acid D. p-chloro benzoic acid

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20. During hemoglobin recycling in the spleen, heme is initially converted into:

A. Bilirubin B. Biliverdin C. Urobilin D. Urobilinogen