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1. @@What might be predicted to happen when the following substance undergoes Friedel-Crafts acylation?

A. Substitution occurs in ring B, p- to the methylene group B. Substitution occurs in ring A, o- to the nitro group C. Substitution occurs in ring A, o- to the methylene group D. Substitution occurs in ring B, m- to the methylene group

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2. Chief active constituent present in Anethum graveolens is –––––––.

A. Fenchone B. Carvone C. Anethole D. Cineole

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3. Mutual funds are regulated in India by which among the following?

A. RBI B. SEBI C. Stock exchanges D. RBI and SEBI both

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4. What is the function of plasmid in r-DNA technology?

A. Host for DNA multiplication B. Vector for transport C. Cutting of DNA D. All of the above

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5. An effective antidote in cyanide poisoning is:

A. Pralidoxime B. Erythrityl trinitrate C. Atropine D. Flumazenil

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6. Allosteric binding means –––––.

A. Binding of the substrate at the active site of the enzyme B. Binding to a site other than the active binding site on the same enzyme C. Binding to the enzyme-substrate complex D. Binding to the endogenous substrate

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7. Most intense peak obtained in mass spectrum is –––––––.

A. Molecular ion peak B. Base peak C. Parent ion peak D. Isotopic peak

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8. IND application filling is done before ––––––.

A. Preclinical study B. Clinical trials C. Patent registration D. Marketing

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9. Which of the following is false regarding Oppenauer oxidation?

A. The alcohol is oxidized with aluminum isopropoxide in excess acetone. B. DMP is used as the reaction catalyst C. Highly selective for secondary alcohols D. Pregnenolone converted to progesterone

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10. Which of the following is true about diastereoisomers?

A. Stereoisomers having multiple chiral centers, cannot be superimposed on the mirror image of another. B. Configuration isomerism and conformational isomerism are also forms of diastereomerism C. Diastereomers have different physical properties and different reactivity. D. All of the above

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11. Electrophilic aromatic substitution reaction using a strong Lewis acid catalyst is known as –––––.

A. Clemmensen reduction B. Wolff-Kishner reduction C. Friedel-Crafts reaction D. None of the above

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12. Splitting of a spectral line into several components due to a magnetic field is known as –––––––.

A. Hamiltonian effect B. Zeeman effect C. Stark effect D. Magnetic effect

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13. Arrange the following in correct bond energy sequence:

A. C-Cl < C-C < C-H < H-H B. H-H < C-H < C-C < C-Cl C. C-Cl < C-H < C-C < H-H D. C-Cl < C-H < H-H < C-C

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14. Salk vaccine is ––––––––.

A. Injected dose of dead poliovirus B. Oral dose of live attenuated poliovirus C. Injected dose of live attenuated poliovirus D. Oral dose of dead poliovirus

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15. Why is PEG used in liposome?

A. To enhance drug loading capacity B. To form an effective bi-layer C. To modify the release of drug D. Avoid detection by the body's immune system

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16. DCC is used in ––––––––.

A. Bechamp reduction B. Benkeser reduction C. Birch reduction D. Solid-phase peptide synthesis

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17. Diazepam is ––––––––.

A. Antipsychotic B. Antidepressant C. Minor tranquilizer D. Hallucinogen

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18. Which of the following is a stop code for translation?

A. UAA B. UGA C. UAG D. All of the above

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19. Which of the following antioxidants is a reducing agent?

A. α-Tocopherol B. BHT C. Vitamin C D. All of the above

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20. Autoimmune disorder myasthenia gravis is caused by ––––––––.

A. Destruction of articular cartilage and ankylosis of the joints B. Circulating antibodies that block ACh receptors at the postsynaptic neuromuscular junction C. Antigen-antibody reaction which destructs the neuromuscular junction D. Deficiency of ACh at the neuronal junction