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1. Biochemical target in pharmaceutical lead discovery can be

A. Enzymes B. Receptor C. Ion channels D. All of these

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2. In which phase micro dosing is directly given to patient without pre-clinical testing

A. 0 Phase B. I Phase C. II Phase D. III Phase

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3. In Michaelis-Menten equation Vmax is measure of

A. Substrate affinity B. Coenzyme activity C. Catalytic efficiency D. Cofactor affinity

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4. Which of the following route is used for BCG vaccine administration

A. Subcutaneous B. Intradermal C. Transdermal D. Oral

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5. Where the Indian Institute of Toxicological Research is located

A. Kanpur B. Izzatnagar C. Allahabad D. Lucknow

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6. The amino acid alanine in our body has configuration

A. S B. R C. Both A and B D. None of these

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7. Which one of the following fatty acid is biosynthesised by human body

A. Lauric acid B. Oleic acid C. Linoleic acid D. Linolenic acid

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8. Rault’s law is related with

A. Osmotic pressure B. Vapour pressure C. Atmospheric pressure D. All

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9. N-allyl derivative of dihydrohydroxymorphine is

A. Naloxone B. Thebaine C. Nalorphine D. Naltrexone

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10. Which of the following compounds will show two spikes at the -N-H stretching

A. A primary amine B. A tertiary amine C. A secondary amine D. All of these

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11. GABAB agonist is

A. Baclofen B. Pergolide C. Bicuculline D. Benzodiazepine

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12. The following drug only acts as arterial vasodilator

A. Hydralazine B. Sodium nitroprusside C. Diazoxide D. Minoxidil

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13. Which of the following species contain highest amount of quinine

A. C. calisaya B. C. officinalis C. C. ledgeriana D. C. succirubra

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14. N-acetyl glucosamine and N-acetyl muramic acid are major cell wall components of

A. Gram positive bacteria B. Gram negative bacteria C. Mycobacteria D. Spirochetes

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15. Solubility of gelatin capsule is decreased by

A. Fumaric acid B. Formalin C. Titanium oxide D. All of the above

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16. In Roche friabilator, plastic chamber revolves at speed

A. 25 rpm B. 50 rpm C. 15 rpm D. 30 rpm

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17. Diffusivity of a solute is affected by

A. Temperature B. Pressure C. Chemical nature D. All of these

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18. has the highest number of U.S. FDA-approved manufacturing facilities outside the United States

A. Brazil B. China C. India D. Philippines

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19. What is action of Digitalis

A. Anti-emetic B. Analgesic C. Increase force of contraction of heart D. Negative ionotropic effect

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20. Capping in tablets mainly due to

A. Less upper punch pressure B. Poor flowability of granules C. Proper formulation design D. Entrapment of air in tablet during compression